Combining Liquisolid and Co-grinding Techniques to Enhance the Dissolution Rate of Celecoxib

Abstract Purpose The classic liquisolid technique is used to enhance the dissolution rate of poorly water-soluble drugs, but in some cases, it impossible reach desired using this alone. Therefore, a novel approach combination ball milling and technology was investigated improve for celecoxib. Methods First, celecoxib dispersed liquid vehicle (PEG 200), then ground mill 3 h. Other excipients, including PVP, microcrystalline cellulose as carrier powder, silica coating material, were added mortar. Dissolution testing carried out simulated intestinal fluid (SIF) gastric (SGF) media. effects aging on hardness profile also studied. X-ray diffraction (XRD) differential scanning calorimetry (DSC) identify changes crystallinity or complex formation. Results formulations showed higher than conventional tablet formulations. Aging did not affect profiles compacts. DSC XRD results suggested that enhanced caused by formation any complexes reduction degree may contribute enhancement. attributed elevated specific surface area drug state. Conclusion combined with an efficient tool enhancing drugs.